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The widely used Quechua name ayahuasca has two highly interrelated yet distinct meanings and referents:

  1. An Amazonian giant vine native to the rainforest containing various harmala alkaloids, generally Banisteriopsis caapi,
  2.  Pharmacologically complex psychoactive infusions prepared from it for shamanic, folk-medicinal, and religious purposes.

Sections of vine are macerated and boiled alone or with leaves from any of a large number of other plants, including Psychotria viridis (chakruna in Quechua) or Diplopterys cabrerana (also known as chacropanga). The resulting brew contains MAO inhibiting harmala alkaloids and the powerful hallucinogenic alkaloid N,N-dimethyltryptamine (DMT), a psychedelic which is active orally only when combined with an MAOI. Harmala alkaloids in Banisteriopsis caapi serve as MAOIs in Ayahuasca. Western brews sometimes substitute plant sources such as Syrian Rue or other harmala containing plants in lieu of the Banisteriopsis caapi vine, but the vine itself is always central to traditional usage.

Ayahuasca Banisteriopsis caapi

Harmala alkaloid

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