headshops Class a information Methamphetamine, dextro-N-α-dimethyl-phenethylamine or desoxyephedrine and popularly shortened to crystal meth or ice or simply meth is an N-methylated analog of amphetamine hydrochloride info head shop

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Headshops information Pharmacology of Methamphetamine
Methamphetamine is a potent central nervous system stimulant which affects neurochemical mechanisms responsible for regulating heart rate, body temperature, blood pressure, appetite, attention, mood and responses associated with alertness or alarm conditions. The methyl group is responsible for the potentiation of effects as compared to the related compound amphetamine, rendering the substance more lipid soluble and easing transport across the blood brain barrier. Methamphetamine causes the norepinephrine and dopamine transporters to reverse their direction of flow. This inversion leads to a release of these transmitters from the vesicles to the cytoplasm and from the cytoplasm to the synapse, causing increased stimulation of post-synaptic receptors. Methamphetamine also indirectly prevents the reuptake of these neurotransmitters, causing them to remain in the synaptic cleft for a prolonged period. Serotonin levels are only weakly affected (ratio NE: DA = 2:1, NE:5HT = 60:1). It is a potent neurotoxin, shown to cause dopaminergic degeneration. The acute effects of the drug closely resemble the physiological and psychological effects of an epinephrine-provoked fight-or-flight response, including increased heart rate and blood pressure, vasoconstriction (constriction of the arterial walls), bronchodilation, and hyperglycemia (increased blood sugar). Users experience an increase in focus, increased mental alertness, and the elimination of fatigue, as well as a decrease in appetite.

Related Topics

Introduction to Methamphetamine, or crystal meth
Pharmacology of Methamphetamine	Production of Methamphetamine
Routes of Administration of Methamphetamine
Methcathinone	Amphetamine

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