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Home - Legal High index  - Ephedrine  -  Neurotoxicity of Ephedrine

Legal Herbal HighsNeurotoxicity of Ephedrine
Ephedrine as a sympathomimetic agent similar in structure and activity to amphetamines, there has been a dispute over whether ephedrine produces some of the same neurodegenerative effects. It has been shown clinically that certain amphetamines (namely (d)-amphetamine and (d)-methamphetamine) can cause varying levels of long-term dopamine depletion in dopamine-rich brain and nervous centers such as the putamen and the basal ganglia.

Several studies have recently compared the quantities of such neurotransmitters as serotonin, dopamine, glutamate, and adrenaline after concurrent administration of ephedrine and various amphetamine-like agents. The results showed that ephedrine has a reduced neurotoxic effect on dopamine than its amphetamine counterparts.

Ephedrine increases serum dopamine levels minimally in comparison with an equivalent dose of dextroamphetamine (Adderall®). Dextromethamphetamine (Desoxyn®) raises dopamine levels dramatically (more than two times that of an equivalent dose of dextroamphetamine). This supports the general consensus that ephedrine has more of a peripheral action on the sympathetic nervous system, whereas amphetamines appear to cross the blood brain barrier more freely and tend to have a stronger central action. The fact that dopamine is believed to play a major role in the addiction response has been used in recent years as justification for controlling the distribution of dextroamphetamine and dextromethamphetamine, along with various other amphetamines.

 

Legal Herbal HighsRelated Topics to Ephedrine
Introduction to Ephedrine Chemistry of Ephedrine
How Ephedrine works on the human body Clinical Use of Ephedrine
Recreational and illicit use of Ephedrine Neurotoxicity of Ephedrine

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